Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.
Pharmacokinetic studies in men with Topicort® (desoximetasone) Ointment % with tagged desoximetasone showed no detectable level (limit of sensitivity: μg/mL) in 1 subject and and μg/mL in the remaining 2 subjects in the blood when it was applied topically on the back followed by occlusion for 24 hours. The extent of absorption for the ointment was 7% based on radioactivity recovered from urine and feces . Seven days after application, no further radioactivity was detected in urine or feces. Studies with other similarly structured steroids have shown that predominant metabolite reaction occurs through conjugation to form the glucuronide and sulfate ester.
Dog food itself can have a positive impact on dogs that are suffering from arthritis. In a clinical study, dogs that were fed a diet specifically formulated for dogs with OA (osteoarthritis) such as Hill's Prescription Diet j/d , a food rich in Omega-3 fatty acids , showed improvement over dogs that had a similar arthritic condition, but that were fed an ordinary diet. The results of the study showed that "more dogs in the test group had a reduction in pain at the end of the 90-day trial." 82% of the dogs in the trial that received the new diet showed improvement.