The purpose of these reactions is to release energy stored in the sugar molecule. To explain that process, one must know that a sugar molecule consists of carbon, hydrogen, and oxygen atoms held together by means of chemical bonds. A chemical bond is a force of attraction between two atoms. That force of attraction is a form of energy. A sugar molecule with two dozen chemical bonds can be thought of as containing two dozen tiny units of energy. Each time a chemical bond is broken, one unit of energy is set free.
Indication for external ozone application include poorly healing wounds, burns, staphylococcal infections, fungal and radiation lesions, herpes simplex and zoster, and gangrene (diabetic or Clostridium). Dosage is adjusted to the condition treated. Gas perfusions may last from 3 to 20 minutes, ozone concentrations varying from 10 to 80 ug/ml (maximum five parts of ozone to 95 parts of oxygen). High ozone concentrations are used for disinfection and cleaning (or debridement), while low concentrations promote epithelialization and healing.[6,15]
However, there are several other lesser-known mechanisms of generating NADPH, all of which depend on the presence of mitochondria. The key enzymes in these processes are: NADP-linked malic enzyme , NADP-linked isocitrate dehydrogenase , NADP-linked glutamate dehydrogenase and nicotinamide nucleotide transhydrogenase.  The isocitrate dehydrogenase mechanism appears to be the major source of NADPH in fat and possibly also liver cells.  Also, in mitochondria, NADH kinase produces NADPH and ADP, using NADH and ATP as substrates.