A key aspect of hair loss with age is the aging of the hair follicle.  Ordinarily, hair follicle renewal is maintained by the stem cells associated with each follicle. Aging of the hair follicle appears to be primed by a sustained cellular response to the DNA damage that accumulates in renewing stem cells during aging.  This damage response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. Proteolysis of collagen leads to elimination of the damaged cells and then to terminal hair follicle miniaturization.
Tang-kuei Tang-kuei Ho-shou-wu Tang-kuei Tang-kuei Peony Peony Hoelen Red peony Red peony Cnidium Cnidium Achyranthes Cnidium Persica Rehmannia Rehmannia, raw Tang-kuei Persica Carthamus Ho-shou-wu Ho-shou-wu Lycium Carthamus Pangolin Carthamus Carthamus Cuscuta Sparganium Artemisia ( liujinu ) Ligustrum Ligustrum Psoralea Zedoaria Gleditsia Cuscuta Cuscuta Bupleurum Pyrolusite ( zhiwu ) Chiang-huo Eclipta Curcuma Saussurea Gastrodia Salvia Turmeric Clove Soja Ginger, fresh Rhubarb Green onion Eupolyphaga In this last group, Qibao Meiran Dan is the same as the Pill for Deficiency of Yin and Blood mentioned above. This Chinese name of this formula is translated in Formulas and Strategies (17) as "Seven-Treasure Special Pill for Beautiful Whiskers." The prescription is attributed to a master herbalist of the Ming Dynasty, Shao Yingjie, but it was recorded by Wang An, in his book Yifang Jijie during the early Qing Dynasty (1682 .). By that time, the formula had become quite popular.